![]() ![]() (Note that, if there is no dosing time specified, the dosing time is assumed to be zero.) Inserting initial time points: If a PK profile does not contain an observation at dose time, Phoenix inserts a value using the following rules. (A profile is identified by a unique combination of sort variable values.) Sorting: Prior to analysis, data within each profile is sorted in ascending time order. Prior to calculation of pharmacokinetic parameters, Phoenix institutes a number of data-checking and pre-treatment procedures as follows. For steady state data, Cmax, Tmax, Cmin and Tmin are found using observations taken at or after the dose time, but no later than dose time+tau. In this instance, the program will estimate the AUC_TAU based on the estimated concentration at 24 hours, and not the concentration at the actual observation time. For example, if dose time=0 and tau=24, the last sample might be at 23.975 or 24.083 hours. However, in most studies, there are sampling time deviations. When using steady-state data, Phoenix computes AUC_TAU from dose time to dose time+tau, based on the tau value set in the Dosing panel. WinNonlin NCA computations are covered under the headings: Computational rules for the NCA engine are discussed in sections:
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |